Exclusion Criteria

Absolute contraindications :

• Patients with joint infection;

• Pregnancy and breast-feeding;

• Local skin infection;

• Ruptured popliteal cyst for Yttrium-89 injection 

• [90Y]Yttrium-citrate is only suitable for the knee joint;

Relative contraindications :

• The radiopharmaceuticals should only be used in children and young patients (<20 years) if the benefit of treatment is likely to outweigh the potential hazards;

• Extensive joint instability with bone destruction;

• Evidence of significant cartilage loss within the joint.